In New Zealand, pharmaceutical preparations containing a monthly dosage of 50 000 IU vitamin D3 might be considered by family doctors for those populations that are at risk a of vitamin D deficiency.12 However, the adequacy of this dose in some populations, especially in Middle Eastern women, remains doubtful.17 Talwar et al.18 predicted that patients with serum-25(OH)D concentrations >45 and <45 nmol/l needed 2800 and 4000 IU/d vitamin D, respectively, to achieve concentrations >75 nmol/l, indicating that dosages >50 000 IU/month might be needed to raise serum-25(OH)D concentrations of Middle Eastern women to at least 75 nmol/l. Rizzoli R, Boonen S, Brandi M-L, Bruyère O, Cooper C, Kanis JA et al. Bone 2001; 29: 428–430. The blood was protected from light and allowed to clot for 30 min and centrifuged for 10 min at 2000 r.p.m. Reference lines at 50 (dotted line) and 75 nmol/l (hyphened line) were added for clarification. Arch Dermatol 1988; 124: 869–871. Sunlight "D"ilemma: risk of skin cancer or bone disease and muscle weakness. (2019), The American Journal of Clinical Nutrition Vieth R, Chan P-CR, MacFarlane GD . Kulie T, Groff A, Redmer J, Hounshell J, Schrager S . Other studies have also reported that larger increases are seen in those with lower baseline levels.18, 20, 23, 35, Lower body fat percentage appeared to be one of the factors influencing a better response to oral vitamin D supplementation. Season is a well-established determinant of vitamin D status.21, 38 In latitudes above 35° (Auckland is at a latitude of 36.5°), synthesis of 25(OH)D decreases in winter.1 The seasonality of vitamin D status was shown by the increase in mean serum-25(OH)D concentration in the placebo group at the final visit (approaching summer). Hosseinpanah F, Pour SH, Heibatollahi M, Moghbel N, Asefzade S, Azizi F . The characteristics of the study population are presented in Table 1. Aliquots of serum were collected in Eppendorf tubes and stored at −80 °C until the analysis of serum-25(OH)D at the end of the study in one batch for each study. In conclusion, the prevalence of vitamin D deficiency/insufficiency is high in Middle Eastern women. eds, Ministry of Health: Wellington, New Zealand, 2012. So, larger doses than monthly 1 00 000 IU are required to shift vitamin D status to ⩾75 nmol/l in the populations with high prevalence of vitamin D insufficiency. Zabihiyeganeh M, Jahed A, Nojomi M . The mean serum-25(OH)D concentration in the placebo group increased from 45.0±18.0 nmol/l at baseline to 54.0±18.0nmol/l at 6 months (P<0.01). Larger dose, lower baseline serum-25(OH)D concentration and lower body fat percentage were significantly associated with larger 6-month change in the serum-25(OH)D concentration. We wish to thank research project manager, Owen Mugridge, and laboratory manager, PC Tong, for their ongoing support and help The study was registered under the Trial registration no: ACTRN12613000383763. Predictors of 6-month change in serum-25(OH)D were dose (B-coefficient±s.e. Furthermore, in Part-I, despite the use of prescribed vitamin D supplements by 30% of the study population, all women had serum-25(OH)D concentrations <50 nmol/l. Thorne Research - Vitamin D-25,000 - Vitamin D3 Supplement (25,000 IU) for Healthy Bones and Muscles - 60 Capsules 4.8 out of 5 stars 80 $33.00 $ 33 . 12/16, and of Part-II by the Health and Disability Ethics Committee: Reference No. Endocr Pract 2009; 15: 35–40. The objectives were to determine vitamin D deficiency and its determinants in Middle Eastern women living in Auckland, New Zealand (Part-I), and to determine serum 25-hydroxyvitamin D (serum-25(OH)D) response to two prescribed vitamin D dosages (Part-II) in this population. Field AP . Medicine Name altavitaD3 25,000 IU oral solution : Active Ingredients Colecalciferol (Vitamin D3) Medicine Name altavitaD3 25,000 IU soft capsules : Active Ingredients Colecalciferol (Vitamin D3) Medicine Name altavitaD3 50,000 IU soft capsules : Active Ingredients Colecalciferol (Vitamin D3) Medicine Name altavitaD3 7,000 IU soft capsules One outlier with baseline serum-25(OH)D concentration of 189 nmol/l was excluded from the end point analysis, but was included in the analyses determining the baseline characteristics. Calcium and albumin were measured by a Flex reagent cartridge system by Siemens Health care Diagnostics (Australia and New Zealand) with a coefficient of variation of 2.2–3.0%. Transformed variables were back transformed into mean (95% confidence interval) from summary statistics. at 4 °C within 2 h of sampling. To record any changes in lifestyle including prescribed medicine and supplement use between the two visits, participants completed the change of lifestyle questionnaire. Google Scholar. At a 6-month visit, all participants in the 50 000 and 1 00 000 IU groups, except for one in the 50 000 IU group, had serum-25(OH)D concentrations ⩾50 nmol/l. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK et al. Descriptive statistics were used for population characteristics. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient-a randomised, placebo-controlled trial. Effect size (r) was calculated using Z/√n and a value of 0.1, 0.3 and 0.5 represents small, medium and large size effect, respectively.36. Our Standards: The Thomson Reuters Trust Principles. The pattern of change in serum-25(OH)D concentrations over the study period (baseline, 3 months and 6 months) within each of the treatment groups have been presented. Part-II was then designed to elucidate these findings. This study was divided into two parts; Part-I was designed as an epidemiological cross-sectional pilot study commencing in July–August 2012 (winter), and Part-II as a 6-month randomised, double-blind, placebo-controlled dose–response trial commencing in late June 2013 (winter) and concluding in late January 2014 (summer). The primary outcome variable was serum-25(OH)D concentration. Blum M, Dolnikowski G, Syoum E, Harris SS, Booth SL, Peterson J et al. N Z Med J 2006; 119: 1241. In the meantime, to ensure continued support, we are displaying the site without styles Furthermore, the baseline blood samples (both studies) were collected in late June-August (winter). Comparable to Turkish women, 45.0% of Iranian women living in Oslo, Norway, had serum levels <20 nmol/l.7 Although no data is available about this population in New Zealand, anecdotal evidence from health service providers suggests that vitamin D deficiency is highly prevalent.10, These women are at a greater risk of vitamin D deficiency owing to many lifestyle risk factors such as conservative clothing style. J Am Board Fam Med 2009; 22: 698–706. In Part-II, women aged 20–50 years (n=62) participated in a randomised, double-blind placebo-controlled trial consuming monthly either 50 000, 100 000 IU vitamin D3 or placebo for 6 months (winter to summer). SAGE: Los Angeles, 2009. We also found a significant interaction between time of follow-up and the dose of treatment, F (2, 73.6)=11.7, P<0.001. Vitamin D supplementation as an adjuvant therapy for patients with T2DM: an 18-month prospective interventional study. There were four women taking multivitamins containing both supplemental calcium and vitamin D, and 11 taking multivitamins containing vitamin D (100–800 IU vitamin D/tablet). A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 2012; 367: 40–49. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Institute of Food, Nutrition and Human Health, Massey University, Auckland, New Zealand, Commonwealth Scientific Industrial Research Organisation, Food and Nutrition Flagship, Adelaide, South Australia, Australia, You can also search for this author in