​. However, not all patients stand to benefit from this treatment due to factors such as genetics, diet, body composition, length of use, and other co-administered substances. ​It is well known that as weight increases growth hormone decreases. It appears that LDN helps with weight loss by affecting the following: Reduces Insulin Resistance - Insulin resistance is a common cause of weight gain, so it makes sense that reducing it will result in weight loss. As always, weight loss medications should never be used in isolation (meaning by themselves) and they should ALWAYS be accompanied by changes to your diet and exercise routine. Above, there are several theories on how LDN causes losing weight. In addition, the dosing of naltrexone in Contrave is higher than I generally recommend. One idea explores the connection between LDN and appetite. If you have questions regarding your health you should seek qualified information from a medical professional or your doctor. Many positive studies include major errors such as low sample sizes, lack of attempts to reproduce results, or failure to control with a placebo group. ​High levels of inflammation cause several hormonal changes which all lead to conditions where weight is gained more easily while simultaneously being more difficult to lose. By relieving inflammatory cytokines and markers of inflammation hormone levels become more regulated and balanced which may allow easier weight loss. Read more here. At this level of 50 to 100 milligrams per dose, Naltrexone blocks the euphoric effects of certain drugs and alcohol to reduce cravings and eliminate the need for harmful substances. Olivier George is a medical writer and head manager of the rehab center in California. Studies have demonstrated LDN’s ability to reduce cravings as well as the need to feel the euphoria that may drive someone to drink or smoke. ​This is where Naltrexone comes into play. This results in temporary weight loss, but the weight is usually regained in a matter of weeks. Naltrexone in low doses seems to attenuate this response and help lower this set point. Studies have shown (2) that using Naltrexone (in this study 75mg) actually helped to lower fasting insulin levels by up to 40%. Wellbutrin + LDN as a combination weight loss medication, improve sleep in patients with complex regional pain syndrome, increase total T3 levels and improve T4 to T3 conversion, thyroid function modulates the metabolism, possibly improving and/or reducing thyrogloblulin antibodies, primarily mediated through hypothalamic function, reduce appetite to reduce total calories consumed, Thyroid Symptoms in Men + How Low Thyroid Causes Low Testosterone, Thyroid Success Story: Adding T3 to NDT for Weight Loss + Energy, Chronic calorie restriction fails 99% of the time in sustaining weight loss, Chronic calorie restriction leads to a compensatory metabolic change which results in a, Generally, prescription weight loss medications target either appetite or metabolism and yet they really don't work that well long term, Reducing appetite may lead to metabolic damage long term as is seen in, Increased insulin resistance (leading to weight gain).